Opening NFL Wild Card Odds and Betting Lines: Rams Are Biggest Favorite

We've reached the 2025-26 NFL postseason.

Odds hit the board before the Baltimore Ravens and Pittsburgh Steelers wrapped up their Sunday Night Football clash, so here's a look at the early NFL Wild Card odds ahead of Super Wild-Card Weekend.

The schedule is set, and the Los Angeles Rams will kick off the weekend as the biggest favorite on the slate against the Carolina Panthers.

NFL odds for Wild Card Weekend

Matchup	Spread	Moneyline	Over/Under
Rams @ Panthers	Panthers +10	Rams -620 Panthers +460	46.5
Packers @ Bears	Bears -1.5	Packers -108 Bears -108	46.5
Bills @ Jaguars	Jaguars +1	Bills -120 Jaguars +102	51.5
49ers @ Eagles	Eagles -3.5	49ers +164 Eagles -196	46
Chargers @ Patriots	Patriots -3.5	Chargers +176 Patriots -210	45.5
Texans @ Ravens/Steelers	Ravens/Steelers TBD	Texans TBD Ravens/Steelers TBD	TBD

Lines as of 1-4

Rams vs Panthers odds (Saturday, 4:30 p.m., FOX)

Opening line

• Panthers +10.5
• Over/Under 46.5
• Read our Rams vs. Panthers picks and predictions (coming soon)

Opening line analysis coming soon!

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Packers vs Bears odds (Saturday, 8 p.m., Prime Video)

Opening line

• Bears -1.5
• Over/Under 46.5
• Read our Packers vs. Bears picks and predictions (coming soon)

Opening line analysis coming soon!

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Bills vs Jaguars odds (Sunday, 1 p.m., CBS)

Opening line

• Jaguars +1.5
• Over/Under 51.5
• Read our Bills vs. Jaguars picks and predictions (coming soon)

Opening line analysis coming soon!

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49ers vs Eagles odds (Sunday, 4:30 p.m., FOX)

Opening line

• Eagles -3.5
• Over/Under 46.5
• Read our 49ers vs. Eagles picks and predictions (coming soon)

Opening line analysis coming soon!

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Chargers vs Patriots odds (Sunday, 8 p.m., NBC)

Opening line

• Patriots -3.5
• Over/Under 45.5
• Read our Chargers vs. Patriots picks and predictions (coming soon)

Opening line analysis coming soon!

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Texans vs Ravens/Steelers odds (Monday, 8 p.m., ESPN)

Opening line

• Spread TBD
• Over/Under TBD

Opening line analysis coming soon!

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This article originally appeared on Covers.com, read the full article here